Prep students have many opportunities to develop physically, socially, and emotionally through participation in a variety of co-curricular and extra-curricular activities. The student government association, debate team, student publications, service clubs, academic honorary societies, band, choir, drill team, cheerleading, visual arts classes and exhibits, drama and musical theater productions, and special interest clubs are representative examples of the more than twenty co-curricular activities available to students.

Prep enjoys statewide and regional recognition for its competitive athletic programs. Varsity teams compete in Class AAA of the Mississippi Private School Association. Prep also competes against schools from outside this association and from other states and regions. Prep teams have won championships in football, basketball, baseball, track, cross-country, soccer, softball, swimming, tennis, and golf. Since 1970, over 170 Prep graduates have participated in collegiate athletics.